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Organic compounds that contain a carboxyl group bonded to an organic functional group; carboxyl groups consist of a carbonyl group bonded to a hydroxy group. Includes compounds that are derived from carboxylic acids.
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A triterpene with antiviral and hepatoprotective activities; inhibits SFV replication in virus-infected Huh7 cells (IC50 = 9.1 µM); improves hepatic function in various rat models of hepatitis at 20 mg/kg
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A synthetic progestogen; prevents the development of osteoporosis in ovariectomized rats at 9 UG/animal per day; inhibits copulatory ovulation in rabbits
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Chemical. CAS 596-09-8. Formula C24H16O7. MW 416.38. Synthetic. FDA is a non-fluorescent hydrophobic fluorescein derivative that can pass through the cell membrane whereupon intracellular esterases hydrolyze the diacetate group producing the highly fluorescent product fluorescein. The fluorescein molecules accumulate in cells that possess intact membranes so the green fluorescence can be used as a marker of cell viability. Cells that do not possess an intact cell membrane or an active metabolism may not accumulate the fluorescent product and therefore do not exhibit green fluorescence. FDA may be used in combination with PI staining as the non-viable cells take up the PI and stain dead cells red whereas viable cells do not take up the PI and should only stain green. This 2-color separation of non-viable and viable cells may provide a more accurate quantitation of cell viability than single color analysis.
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Chemical. CAS 77084-71-0. Formula C32H20O7. Molecular Weight 516.5. Naphthofluorescein-diacetate is a non-fluoresent compound that is hydrolyzed by esterases to the fluorescent compound Naphthofluorescein. Spectral data lambdaex 594 nm lambdaem 663 nm in 0.1 M Tris pH 9.0 esterase. The fluorescent naphthofluorescein has been shown to be an inhibitor of furin.
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Menadiol Diacetate (CAS 573-20-6) is a synthetic derivative of vitamin K investigated for its regulatory effects on cellular signaling pathways and enzyme activities In experimental studies Menadiol Diacetate has been shown to induce S phase arrest in the cell cycle leading to apoptotic cell death This compound is utilized in research focused on cancer and related diseases providing a tool for exploring mechanisms of cell proliferation and apoptosis in vitro
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CA-074 Me (CAS 147859-80-1) is a cell-permeable methyl ester derivative of CA-074 functioning primarily as a selective inhibitor of cathepsin B It exhibits potent inhibitory activity against cathepsin B (IC50 36 3 nM) In cultured human gingival fibroblasts CA-074 Me effectively suppresses cathepsin B activity while moderately reducing combined cathepsin B and L activities Under strong reducing conditions (e g presence of DTT or GSH) CA-074 Me inhibits cathepsin L substantially Thus it is widely utilized in biomedical research to study lysosomal enzyme functions and roles of cathepsins in cellular processes
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Medchemexpress, HY-12466 10mg Z-DEVD-FMK Caspase-3 Inhibitor CAS:210344-95-9 Formula:C30H41FN4O12 IC50: 18 μM (caspase-3) Purity:98% Z-DEVD-FMK is a specific and irreversible caspase-3 inhibitor with IC 50 of 18 μM. Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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2-Hydroxybutyric acid is an endogenous metabolite derived from 2-Aminobutyric acid. It is identified as a potential biomarker for type 2 diabetes and preeclampsia. This compound has demonstrated the ability to prevent acetaminophen (AP)-induced liver injury in studies, enhancing cell viability and reducing AP-induced cytotoxicities in various cell lines and in vivo models. It also plays a role as a coproduct of insulin resistance.
Potential biomarker for type 2 diabetes and preeclampsia.
Prevents acetaminophen-induced liver injury.
Enhances cell viabilities and reduces AP-induced cytotoxicities.
Normalizes gene expressions related to inflammation, oxidative stress, cell proliferation, and DNA damage.
Functions as a coproduct of insulin resistance.
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